Drug Purity Report Week 43, 2026
This article has been translated to English.
Drug Purity Report #43/26. Welcome to “last week on drugs”, the news series by PRO Test that brings you fresh drug purity updates from the clandestine market. In this week’s edition: PMMA risk continues, NEP remains the leading missold cathinone and novel depressants found in supposed XANAX.
Available lab results originate mostly in Western Europe, but the detected patterns are likely to have a much wider reach.
Data fatigue is real, so here we come to give you the gist of what’s going on out there. For more details, photos, and other information on thousands of drugs, head out straight to the DrugsPRO app.
PMMA continues to be missold as MDMA under various pill designs. So far confirmed this year in at least Trump, Gorilla, Red Bull, Club 555, Mitsubishi and Scorpion pills, but warning is not limited to those. While somewhat similar in structure to MDMA, the PMMA, perhaps a product of botched synthesis, poses a great risk of serotonin syndrome, and much weaker recreational effects, posing a high risk of accidental overdose. PMMA is a weaker, but still dangerous, analog of PMA, the most deadly MDMA adulterant. Warning: PMMA is being sold mixed with MDMA, requiring a lab analysis or TLC MDMA Purity Test Kit to detect it, not only reagent tests.
NEP (N-Ethylpentedrone) remains one of the main adulterants missold as 3-MMC and 4-MMC (Mephedrone), the most commonly sought out cathinones. Unlike MMC or even CMC, NEP does not offer same serotonine release effect, but a much stronger stimulation instead, likening the experience more to meth than MDMA, if seeking comparison to more old school drugs. NEP is also much more potent per dose, and is being found both pure and mixed in with other cathinones, making detection harder, although not impossible.
Medetomidine, a veterinary anesthetic medication with potent sedative effects has been found in a black market Xanax knock-off. This class of compounds is being as of recent years increasingly found in so-called “downers”, mostly benzodiazepines and opioids. Interestingly, in pills it was found pure, which means a simple quick test for presence of a benzodiazepine would rule it out. Unlike benzos, medetomidine can cause lethal respiratory depression.
Scam of the Week
Samples that were not what they were sold as. Substitutions like these can be picked up with a test kit before anything is taken.
| Sold as | Actually | Samples |
|---|---|---|
| Benzodiazepin | Medetomidine | 1 sample |
| MDMA | PMMA | 1 sample |
| 3-MMC | NEP | 2 samples |
Dishonourable mentions from this week. What the lab actually found, with the date and the place it was checked.
| What was in it | Sold as | When | Where |
|---|---|---|---|
| PMMA | MDMA | 19 October | Tournai, Belgium |
| PMMA, MDMA 2mg | 23 October | Zürich, Switzerland | |
| 4-CMC 64.9%, NEP 21.5% | 3-MMC | 19 October | Berlin, Germany |
| 4-CMC 66.1%, NEP 15.3% | 4-MMC | 19 October | Berlin, Germany |
| NEP 77.7%, 4-CMC 3% | 3-MMC | 19 October | Berlin, Germany |
| NEP | 4-MMC | 20 October | Zürich, Switzerland |
| Ketamine 91.7% | Mescaline | 20 October | Zürich, Switzerland |
| N-Desalkylflurazepam | Xanax | 21 October | Zürich, Switzerland |
| NEP | 3-MMC | 21 October | Zürich, Switzerland |
| MDMB-INACA, 5F-ADB | 23 October | Ljubljanskem Zaporu, Slovenia |
Additional dishonourable mentions: PMMA sold as MDMA (19 October, Tournai, Belgium) and a second PMMA sample carrying 2mg of MDMA (23 October, Zürich, Switzerland). Four more NEP samples went out as 3-MMC or 4-MMC: 77.7% NEP beside 4-CMC, and two 4-CMC mixtures carrying 21.5% and 15.3% NEP (19 October, Berlin, Germany), with one more sold as 3-MMC (21 October, Zürich, Switzerland).
Last Week at a Glance
- 57 samples from 6 countries (Austria, Belgium, Germany, Slovenia, Spain and Switzerland) were included this week.
- 49 samples contained a quantified result, including 31 pills and 2 LSD samples.
- 17 samples contained more than one detected ingredient.
- MDMA was typically 166mg this week, against 156mg across the twelve months before.
What People Searched For
Below is a list of substances people are searching for in the DrugsPRO app when coming from Google, ordered by how often they were searched over the past week. Something suddenly on the rise can stand out in search interest before it shows up in lab results.
| # | Substance | Trend |
|---|---|---|
| 1 | Ethylbromazolam | rising |
| 2 | 4-Pro-MET | rising |
| 3 | NEP | steady |
| 4 | 4-Pro-MET | rising |
| 5 | 1Fe-LSD | cooling |
| 6 | 3-FPO | rising |
| 7 | Cyclazodone | rising |
| 8 | Flubrotizolam | cooling |
| 9 | Ethylflualprazolam | cooling |
| 10 | 3-Me-PCPy | steady |
Substances in Focus
Three substances covered in more detail this week: what they are, and how they are dosed and how long they last by route of administration. Doses and durations come from the DrugsPRO library and describe the substance itself, not any tested sample.
PMMA
PMMA, para-methoxymethylamphetamine, is a structural hybrid of PMA and methamphetamine that is sold as ecstasy, historically under logos such as Mitsubishi and Jumbo. Read more on euda.europa.eu
Oral
No dose range is shown for this substance. There is no dose that makes it safer, and drug-checking services advise against taking it at all.
NEP
NEP is a substituted cathinone that produces stimulating, euphoric, and mildly entactogenic effects. It first appeared on the research chemical market in 2016 as a contemporary designer drug. Read more on dose.wiki
Source: tripsit.me, psychonautwiki.org
Oral
Dose range
Duration
Onset 0.17-0.33 hPeak 1-2 hOffset 2-4 h
Total: 3-6 h. After effects: 0.5-3 h.
Insufflated
Dose range
Duration
Onset 0.083-0.25 hCome-up 0.1-0.2 hPeak 0.5-1.5 hOffset 0.5-1.5 h
Total: 2-4 h. After effects: 0.5-2 h.
Smoked
Dose range
Duration
Onset 0.08 h
Source: dose.wiki, tripsit.me, psychonautwiki.org, substance.wiki
Ketamine
Ketamine is a dissociative anesthetic of the arylcyclohexylamine class, developed in the early 1960s by Parke-Davis Laboratories as a replacement for phencyclidine (PCP). Widely employed in both human and veterinary medicine, it is considered the archetypal dissociative substance. Read more on dose.wiki
Source: erowid.org, tripsit.me, psychonautwiki.org
Insufflated
Dose range
Duration
Onset 0.02-0.08 hCome-up 0.08-0.33 hPeak 0.25-0.5 hOffset 0.75-2 h
Total: 0.75-2 h. After effects: 4-8 h.
Oral
Dose range
Duration
Onset 0.17-1.25 hCome-up 0.08-0.33 hPeak 0.75-1.5 hOffset 2-3 h
Total: 1-3 h. After effects: 2-12 h.
Rectal
Dose range
Duration
Onset 0.02-0.08 hCome-up 0.08-0.33 hPeak 0.33-0.75 hOffset 0.5-1.5 h
Total: 1-2 h. After effects: 2-4 h.
Intramuscular
Dose range
Duration
Onset 0.02-0.05 hPeak 0.5-1 h
After effects: 1-4 h.
Source: dose.wiki, tripsit.me, psychonautwiki.org, substance.wiki
Bars are drawn to the same scale within a substance. An open-ended band such as “175+ mg” is shown reaching the end of the scale.
Purity and Content
Below, the big number in each row is the typical result for 19–25 October 2026: half the samples came in stronger, half weaker. The smaller one in brackets is the same thing measured over the last twelve months.
| Samples | Substance | Typical purity / content |
|---|---|---|
| 3 | MDMA | 166mg (156mg*) half of samples 144.5 to 168.5mg |
* the 12 months before this week, not the same week a year ago
Most Common Adulterants and Other Impurities
Across the last 365 days, 2,496 mixed samples contained 143 distinct additional ingredients.
| Samples | Additional ingredient | Share of substance mixtures | Most often found with |
|---|---|---|---|
| 769 | Unknown | 49.5% of cocaine samples · lower than last week | Cocaine, MDMA, Ketamine |
| 694 | Caffeine | 81.2% of amphetamine samples · lower than last week | Amphetamine, Heroin, MDMA |
| 154 | Paracetamol | 73.9% of heroin samples · lower than last week | Heroin, Cocaine, Ketamine |
| 117 | MDMA | 32.6% of ketamine samples · higher than last week | Ketamine, 2C substances, Mephedrone |
| 115 | Procaine | 21.6% of cocaine samples · higher than last week | Cocaine, Mephedrone, Ketamine |
| 109 | 4-CMC | 30.6% of mephedrone samples · higher than last week | Mephedrone, MDMA, Ketamine |
| 108 | iso-LSD | 93.9% of LSD samples · lower than last week | LSD |
| 101 | Ketamine | 12.4% of MDMA samples · higher than last week | MDMA, 2C substances, Amphetamine |
| 60 | Phenacetin | 8.9% of cocaine samples · lower than last week | Cocaine, Heroin, Ketamine |
| 58 | Levamisole | 11.9% of cocaine samples | Cocaine, Ketamine |
| 52 | 2-MMC | 10% of mephedrone samples · higher than last week | Mephedrone, Ketamine, MDMA |
| 43 | 4-BEC | 18.8% of mephedrone samples · lower than last week | Mephedrone, Ketamine |
| 42 | Amphetamine | 3.1% of MDMA samples | MDMA, Ketamine, Cocaine |
| 41 | Cocaine | 8% of ketamine samples | Ketamine, Amphetamine, Heroin |
| 40 | 2C-B | 6.3% of MDMA samples · higher than last week | MDMA, Ketamine, Amphetamine |
| 39 | 4-MMC | 5.5% of MDMA samples · lower than last week | MDMA, Ketamine, Cocaine |
| 34 | 1-PEA | 7.1% of amphetamine samples · higher than last week | Amphetamine, MDMA |
| 33 | Synthesis Impurity | 3.9% of MDMA samples · higher than last week | MDMA, 2C substances, Ketamine |
| 27 | d-8-Tetrahydrocannabinol | 26.7% of THC samples · lower than last week | THC/cannabinoids |
| 27 | DPIA | 5.8% of amphetamine samples | Amphetamine |
Impurities Detected This Week
MDMA: 4-CMC (1), 4-MMC (1), Diluent (1), PMMA (1), Synthesis Impurity (1)
Amphetamine: Caffeine (1)
2C substances: Unknown (2)
LSD: iso-LSD (1)
THC/cannabinoids: 5F-ADB (1), d-8-Tetrahydrocannabinol (1), Free Cbd (1), Free Thc (1)
Mephedrone: 4-CMC (1), MDMA (1), Unknown (3)
Remaining detected substances: 2-MMC (2), 3-CMC (1), 4-CMC (5), 5F-ADB (1), MDMB-INACA (1), Medetomidine (1), NEP (5), Norflurazepam (1), PMMA (1)
Data Sources
This report is based on drug-checking data published by: addiction-neuchatel.ch, ailaket.com, BAONPS, CanTEST, checkit.wien, contact-suchthilfe.ch, DILU, drogart.org, drogenarbeitz6.at, drugchecking.berlin, drugchecking.ch, druglab.fr, DrugsData, École des sciences criminelles (ESC), energycontrol.org, eurotox.org, IRM Basel, knowyourstuff.nz, modusvivendi-be.org, neutravel.net, nightlifevaud.ch, NSW Health, nuit-blanche.ch, Pharmazeutischen Kontrolllabor Bern, Pill Testing Australia, raveitsafe.ch, Reseachem GmbH, saferdancebasel.ch, SaferParty.ch, stoftest.org, toxibot.com, tragwerk-luzern.ch, Trimbos, triptalks.at, Université Lausanne, Victorian Department of Health, Victorian Pill Testing Service, wedinos.wales.
All of this data is available at your fingertips in the DrugsPRO app for Android, iOS, and the web.
Drug-checking results describe tested samples only and are not representative of the entire market.
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No test result can tell you a substance is safe. No substance is 100% safe.This article is published for harm reduction purposes. It does not encourage the use of psychoactive substances and does not replace medical advice.