Hofmann Reagent Test Instructions

The Hofmann (p-DMAB-TS) reagent test, also known as the modified Ehrlich test, is a chemical assay used to detect and identify the presence of various substances, including tryptamines, lysergamides and other indole-based psychoactive compounds. This test involves the reaction of the substance with p-dimethylaminobenzaldehyde (p-DMAB) and ferric chloride. The resulting color change indicates the presence of certain compounds, aiding in the identification of most notably LSD. This modified Ehrlich test, which remains a valuable tool in forensic and analytical chemistry.

Hofmann reagent color reactions

Expected color changes for the Hofmann reagent, from the PRO Test reagent chart.

SubstanceExpected reaction
2C-BNo color change
DMTYellow
LSDBlue
KetamineNo color change
AmphetamineNo color change
MethamphetamineNo color change
MephedroneNo color change
MDANo data
MDMANo color change
CocaineNo color change
OxycodoneNo color change

Reagents indicate presence, not purity or quantity. A reaction that differs from the expected color is a reason to test further, not proof of a particular substance.

Hofmann reagent is a common drug testing kit for psychedelics. Used with Ehrlich reagent Hofmann test is best for LSD, DMT and more.

How to test?

How to use reagent tests

Watch how to use Hofmann reagent:

Watch how to use Hofmann reagent:

Questions?

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A positive or negative Hofmann testing kit result does not indicate if a substance is safe. No substance is 100% safe.

No test result can tell you a substance is safe. No substance is 100% safe.This article is published for harm reduction purposes. It does not encourage the use of psychoactive substances and does not replace medical advice.