Hofmann Reagent Test Instructions
The Hofmann (p-DMAB-TS) reagent test, also known as the modified Ehrlich test, is a chemical assay used to detect and identify the presence of various substances, including tryptamines, lysergamides and other indole-based psychoactive compounds. This test involves the reaction of the substance with p-dimethylaminobenzaldehyde (p-DMAB) and ferric chloride. The resulting color change indicates the presence of certain compounds, aiding in the identification of most notably LSD. This modified Ehrlich test, which remains a valuable tool in forensic and analytical chemistry.
Hofmann reagent color reactions
Expected color changes for the Hofmann reagent, from the PRO Test reagent chart.
| Substance | Expected reaction |
|---|---|
| 2C-B | No color change |
| DMT | Yellow |
| LSD | Blue |
| Ketamine | No color change |
| Amphetamine | No color change |
| Methamphetamine | No color change |
| Mephedrone | No color change |
| MDA | No data |
| MDMA | No color change |
| Cocaine | No color change |
| Oxycodone | No color change |
Reagents indicate presence, not purity or quantity. A reaction that differs from the expected color is a reason to test further, not proof of a particular substance.
Hofmann reagent is a common drug testing kit for psychedelics. Used with Ehrlich reagent Hofmann test is best for LSD, DMT and more.
How to test?
Questions?
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A positive or negative Hofmann testing kit result does not indicate if a substance is safe. No substance is 100% safe.
No test result can tell you a substance is safe. No substance is 100% safe.This article is published for harm reduction purposes. It does not encourage the use of psychoactive substances and does not replace medical advice.



